Study of biochemical and hormonal data in idiopathic scoliosis in girls

Abstract

Basic cause and factors determining the progression of idiopathic scoliosis are assumed to be multifarious. A deviating growth pattern has also been suspected. The influence of certain bone and growth-stimulating hormones and related biochemical values has been studied in girls with idiopathic scoliosis compared to controls. The mineral content (S-Ca, S-P and S-Alp) did not differ between idiopathic scoliosis and controls. a2-macroglobulin was slightly increased in the scoliotic group in all ages. Morning fast GH and Somatomedin A level in serum were also increased in the scoliotic group. Even a significant increase of 17-oxosteroids are metabolites of androgens in girls. 17-oxosteroids in urine mainly metabolites of cortisol, neither calcitonin or parathyroid hormone, in contrary, did not differ between scoliosis and controls.