The effect of specific antibodies on the inhibition of leucocyte migration caused by staphylococcal peptidoglycan

Abstract

Specific antibodies to the various antigenic determinants of staphylococcal peptidoglycan are tested for neutralization of the inhibiting effect of peptidoglycan on leucocyte migration. Antibodies to the C-terminal D-Ala-D-Ala group of pentapeptides and to the C-terminal of the glycine bridge showed high neutralizing effect, whereas that of antibodies to the tetrapeptide and to the glycan chain was negligible. The observed neutralization of antibodies against the outermost parts of peptide chains may be due to the inhibition of contact between peptidoglycan and cells.