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. 1980 Oct 15;192(1):381-3.
doi: 10.1042/bj1920381.

Regulation of actin polymerizaton in rat islets of Langerhans

S L Howell, M Tyhurst

Regulation of actin polymerizaton in rat islets of Langerhans

S L Howell et al. Biochem J. .

Abstract

A DNAase-inhibition assay was used to determine the proportions of globular (G-) and filamentous (F-) actin in islets of Langerhans after incubation in various conditions, or after subcellular fractionation. Stimulation of insulin secretion resulted in an ATP-dependent increase in the proportion of F-actin present; fractionation showed 80-90% of the actin to be present in the final supernatant.

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