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. 1981 Oct;5(4):219-28.
doi: 10.1016/0165-022x(81)90046-4.

A highly sensitive technique for staining DNA and RNA in polyacrylamide gels using silver

T Boulikas, R Hancock

A highly sensitive technique for staining DNA and RNA in polyacrylamide gels using silver

T Boulikas et al. J Biochem Biophys Methods. 1981 Oct.

Abstract

A technique is described for staining DNA in polyacrylamide gels with silver. It is rapid, requiring about 30 min for whole staining and development procedure, very simple and at least 20 times more sensitive than ethidium bromide for the staining of double-stranded DNA in polyacrylamide gels. This technique can also be applied for the staining of denatured, single-stranded DNA as well as RNA after their electrophoretic separation on polyacrylamide gels, having the same sensitivity as for double-stranded DNA fragments.

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