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Review
. 1981 Jul;87(1):17-62.
doi: 10.1016/0165-1110(81)90003-8.

Sister-chromatid exchanges: a report of the GENE-TOX program

S A Latt, J Allen, S E Bloom, A Carrano, E Falke, D Kram, E Schneider, R Schreck, R Tice, B Whitfield, S Wolff
Review

Sister-chromatid exchanges: a report of the GENE-TOX program

S A Latt et al. Mutat Res. 1981 Jul.

Abstract

The effects of a number of chemicals on sister-chromatid exchange (SCE) frequencies in in vivo and in vitro systems are reviewed. Standardized protocols for future SCE testing in important systems, as well as for evaluation of test results, are presented. Data reported thus far suggest that SCE analysis may prove useful, especially at a secondary level, as a test of mutagenic carcinogens. Strengths and limitations of SCE analysis are summarized as a guide for future evaluation and use of this procedure.

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