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. 1982 Jan 21;295(5846):206-8.
doi: 10.1038/295206a0.

Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides

U Gubler, P Seeburg, B J Hoffman, L P Gage, S Udenfriend

Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides

U Gubler et al. Nature. .

Abstract

Molecular cloning and DNA sequencing have yielded considerable structural information about proenkephalin. All previously characterized intermediate peptides of the enkephalin pathways in bovine adrenal medulla have now been aligned into an unambiguous primary structure. Two basic amino acid residues serve as processing signals for release of each of the different components.

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