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Comparative Study
. 1982;67(3):284-6.
doi: 10.1159/000233032.

Selective inhibition by betamethasone of allergen-induced release of SRS-A from human lung

C V Hammond, M D Hammond, W A Taylor
Comparative Study

Selective inhibition by betamethasone of allergen-induced release of SRS-A from human lung

C V Hammond et al. Int Arch Allergy Appl Immunol. 1982.

Abstract

Passively sensitized human lung, when incubated with the appropriate allergen, released histamine and slow-reacting substance (SRS-A). Betamethasone sodium phosphate (5-100 microgram/ml), preincubated with the lung overnight, suppressed, in a dose-related manner, the release of SRS-A without having an effect on the release of histamine. Preincubation for only 1 h produced little effect on the release of SRS-A or of histamine. These results may help to explain some of the beneficial effects of glucocorticoids in allergic asthma.

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