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. 1982 Apr 1;155(4):1204-9.
doi: 10.1084/jem.155.4.1204.

Antigen-specific production of immune interferon by T Cells lines

J L McKimm-Breschkin, P L Mottram, W R Thomas, J F Miller

Antigen-specific production of immune interferon by T Cells lines

J L McKimm-Breschkin et al. J Exp Med. .

Abstract

Continuous cultures of T cells reactive to the hapten 4-ethoxymethylene-2-phenyloxazolone were tested for interferon production after antigenic stimulation in vitro. Induction of interferon was antigen-specific and also restricted by the I region of the major histocompatibility complex. Kinetics of antigen induced interferon production were different from those reported for mitogen induced synthesis.

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