Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Jun;128(6):2804-6.

A monoclonal antibody directed against the HLA-Bw6 epitope

S F Radka, D D Kostyu, D B Amos
  • PMID: 6176653

A monoclonal antibody directed against the HLA-Bw6 epitope

S F Radka et al. J Immunol. 1982 Jun.

Abstract

A cytotoxic monoclonal antibody, SFR8-B6, produced by immunizing KGH rats with partially purified glycoprotein from JY, a human B lymphoblastoid cell line, detects HLA-Bw6, a unique public antigen on the HLA-B molecule. By cytotoxicity, SFR8-B6 has complete concordance with the presence of Bw6 as defined by alloantisera, and its reactivity segregates with HLA in families. Because sera detecting Bw4 and Bw6 are rare, this monoclonal antibody has value as a perpetual standard. In addition, SFR8-B6 offers potential as a probe for investigating the molecular relationships of HLA antigens.

PubMed Disclaimer

Publication types