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. 1982 Jan;15(1):71-7.
doi: 10.1007/BF00375504.

Serological cross-reactivity between products of separate I regions

D Birnbaum, M Pla, M Colombani, J Colombani

Serological cross-reactivity between products of separate I regions

D Birnbaum et al. Immunogenetics. 1982 Jan.

Abstract

A B10.S(7R) anti-B10.S(9R) serum (anti-IJEkCd) contained, as expected, antibodies specific for the I-E-subregion-encoded determinant Ia.7. However, tests on recombinant haplotypes demonstrated a series of unexpected weak extrareactions which could be interpreted to be directed against antigenic determinants encoded in the I-A subregion of the H-2 complex. The same type of extrareaction was observed in eluates from I-As, I-Ek cells coated with A.TH anti-A.TL (I-As, I-Ek anti-I-Ak, I-Ek) serum. This reactivity in serum and eluates could be interpreted as cross-reactivity between products of the I-E and I-A subregions.

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