doi: 10.1016/0304-3940(82)90345-7.
Differential sensitivity of presumed dopaminergic and non-dopaminergic neurones in rat substantia nigra to electrophoretically applied substance P
- PMID: 6178059
- DOI: 10.1016/0304-3940(82)90345-7
Item in Clipboard
Differential sensitivity of presumed dopaminergic and non-dopaminergic neurones in rat substantia nigra to electrophoretically applied substance P
Neurosci Lett.
.
Abstract
Substance P (SP) was administered by microelectrophoresis to physiologically identified substantia nigra neurones in halothane anaesthetized rats. Dopaminergic neurones of the substantia nigra compacta (SNC) were markedly less sensitive to SP than non-dopaminergic cells of the substantia nigra reticulata (SNR) when the peptide was administered with the same micropipettes. Identified substantia nigra neurones were also differentially sensitive to other putative transmitters including dopamine, 5-HT and acetylcholine. No interactions could be demonstrated between SP and the responses to other transmitters.
Similar articles
-
The influence of striatal stimulation and putative neurotransmitters on identified neurones in the rat substantia nigra.Brain Res. 1981 May 18;212(2):345-59. doi: 10.1016/0006-8993(81)90467-4. Brain Res. 1981. PMID: 6112050
-
Dopaminergic activation of reticulata neurones in the substantia nigra.Nature. 1980 May 22;285(5762):240-1. doi: 10.1038/285240a0. Nature. 1980. PMID: 7374778
-
Effects of GABA, dopamine, and substance P on the release of newly synthesized 3H-5-hydroxytryptamine from rat substantia nigra in vitro.Naunyn Schmiedebergs Arch Pharmacol. 1978 Oct;304(3):271-5. doi: 10.1007/BF00507968. Naunyn Schmiedebergs Arch Pharmacol. 1978. PMID: 714184
-
The electrophysiological actions of dopamine and dopaminergic drugs on neurons of the substantia nigra pars compacta and ventral tegmental area.Life Sci. 1992;51(10):711-8. doi: 10.1016/0024-3205(92)90479-9. Life Sci. 1992. PMID: 1355254 Review.
-
Neurotransmitter receptors and ionic conductances regulating the activity of neurones in substantia nigra pars compacta and ventral tegmental area.Prog Brain Res. 1993;99:251-76. doi: 10.1016/s0079-6123(08)61351-5. Prog Brain Res. 1993. PMID: 7509080 Review. No abstract available.
Cited by
-
The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro.Br J Pharmacol. 1992 Jan;105(1):3-5. doi: 10.1111/j.1476-5381.1992.tb14199.x. Br J Pharmacol. 1992. PMID: 1375857 Free PMC article.
-
Intrinsic and integrative properties of substantia nigra pars reticulata neurons.Neuroscience. 2011 Dec 15;198:69-94. doi: 10.1016/j.neuroscience.2011.07.061. Epub 2011 Aug 2. Neuroscience. 2011. PMID: 21839148 Free PMC article. Review.
-
Tissue levels and in vivo release of tachykinins and GABA in striatum and substantia nigra of rat brain after unilateral striatal dopamine denervation.Exp Brain Res. 1989;74(3):527-34. doi: 10.1007/BF00247354. Exp Brain Res. 1989. PMID: 2468514
-
Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa.Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3363-7. doi: 10.1073/pnas.94.7.3363. Proc Natl Acad Sci U S A. 1997. PMID: 9096399 Free PMC article.
-
Electrophysiological actions of nicotine on substantia nigra single units.Br J Pharmacol. 1985 Aug;85(4):827-35. doi: 10.1111/j.1476-5381.1985.tb11081.x. Br J Pharmacol. 1985. PMID: 4041681 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
