doi: 10.1126/science.6178165.
Presynaptic location and axonal transport of beta 1-adrenoreceptors in the rat brain
- PMID: 6178165
- DOI: 10.1126/science.6178165
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Presynaptic location and axonal transport of beta 1-adrenoreceptors in the rat brain
Science.
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Abstract
Interruption of the ascending noradrenergic neurons of the locus coeruleus in the rat forebrain with 6-hydroxydopamine produced a progressive accumulation, proximal to the lesion, of tritiated dihydroalprenolol binding activity over 2 days. This accumulation could be blocked by interrupting the neurons closer to their cell bodies. Competitive binding studies with the beta 2 agonist Zinterol suggested that the accumulated beta-receptors were primarily of the beta 1 subtype. These results suggest that, in the rat brain, some beta 1-adrenoreceptors are located in presynaptic, noradrenergic locus coeruleus neurons and are transported in their axons.
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