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. 1982 Apr 1;31(7):1449-53.
doi: 10.1016/0006-2952(82)90044-2.

Effects of flavonoids and transitional metal cations on antigen-induced histamine release from human basophils

E Middleton Jr, G Drzewiecki

Effects of flavonoids and transitional metal cations on antigen-induced histamine release from human basophils

E Middleton Jr et al. Biochem Pharmacol. .

Abstract

Structure-activity relationship studies have been performed on the inhibition of antigen-induced histamine release from human basophils by various naturally occurring flavonoids. Quercetin was the most active compound. Of the transitional metal ions, Cu2+ most effectively blocked the inhibitory activity of quercetin, possibly through a chelation mechanism.

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