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Case Reports
. 1982 Mar;138(2):187-90.
doi: 10.1007/BF00441152.

Subacute sclerosing panencephalitis in a brother and sister. Therapeutic trial of fibroblast interferon

C R Bartram, J Henke, J Treuner, M Basler, A Esch, W Mortier
Case Reports

Subacute sclerosing panencephalitis in a brother and sister. Therapeutic trial of fibroblast interferon

C R Bartram et al. Eur J Pediatr. 1982 Mar.

Abstract

This paper describes the very rare occurrence of subacute sclerosing panencephalitis (SSPE) in two siblings: a Turkish boy and his younger sister. The clinical picture was characteristic, and the diagnosis was confirmed in both cases by appropriate laboratory examination. The interval between the occurrence of the first neurological symptoms in the boy, and subsequently in the girl was four years. Study of HLA- and 27 other polymorphic marker-systems did not reveal linkage to one of the systems tested. Therapeutic trials in the girl included intravenous and intraventricular application of a total of 87 X 10(6) U human fibroblast interferon (Hu INF-beta) over 21 days. However, up to 3 months after the end of interferon administration there were no significant changes in the girl's condition.

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References

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