Comparative Study
doi: 10.1111/j.1399-0039.1982.tb01427.x.
A monoclonal antibody recognizing a determinant common to HLA-A3 and A11
- PMID: 6179256
- DOI: 10.1111/j.1399-0039.1982.tb01427.x
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Comparative Study
A monoclonal antibody recognizing a determinant common to HLA-A3 and A11
Tissue Antigens.
1982 Feb.
Abstract
Spleen cells from a mouse immunized with an AML cell expressing HLA-A3 produced a hybridoma secreting an anti-HLA-A3, A11 monoclonal antibody, 26D3. By complement-dependent cytotoxicity at dilutions to 1:10(4) the ascites antibody lysed 13/13 A3, 15/15 A11, and 8 other lymphocytes from a panel of 98 donors. The 26 D3 immunoprecipitated a molecule consisting of subunits of 44,000 and 12,000 daltons. Monoclonality of the antibody was demonstrated by isoelectric focusing and protein A affinity chromatography.
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