[In vivo induction of antigenic modulation in man by an anti-T cell monoclonal antibody (author's transl)]
[Article in
French]
- PMID: 6179583
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[In vivo induction of antigenic modulation in man by an anti-T cell monoclonal antibody (author's transl)]
[Article in
French]
C R Seances Acad Sci III.
.
Abstract
The anti-T cell monoclonal antibody OKT3 was administered to renal allograft recipients. A dramatic depletion of peripheral T cells was immediately observed followed, after 2-5 days, by the reappearance of a limited but significant number of or OKT3-4+ or OKT3-8+T cells showing antigenic modulation of the OKT3-defined antigen. These cells recovered the OKT3 receptor after overnight in vitro incubation.
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