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. 1981 Feb;1(2):245-51.
doi: 10.1089/jir.1981.1.245.

Isolation of a Biologically active fragment of human alpha interferon

I A Braude, L S Lin, W E Stewart 2nd

Isolation of a Biologically active fragment of human alpha interferon

I A Braude et al. J Interferon Res. 1981 Feb.

Abstract

When treated with pepsin under limited digestion conditions, human leukocyte-derived alpha interferon (HulFN-alpha) is partially inactivated. While the initial HulFN-alpha preparation is about equally active on human and on bovine cells, the residual antiviral activity of HulFN-alpha after pepsin treatment is significantly more active on bovine cells than on human cells. Furthermore, pepsin-treated HulFN-alpha, when assayed on bovine cells, yields an active production which is smaller and antigenically distinguishable from the native forms of HulFN-alpha.

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