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. 1982 Sep 1;156(3):744-55.
doi: 10.1084/jem.156.3.744.

Multiple human beta interferon genes

A D Sagar, P B Sehgal, D L Slate, F H Ruddle

Multiple human beta interferon genes

A D Sagar et al. J Exp Med. .

Abstract

Analysis of human beta interferon (IFN) mRNA preparations obtained from poly(I) . poly (C)-induced human diploid fibroblasts (FS-4) and from several similarly induced human-mouse somatic cell hybrids by electrophoresis through agarose-CH3HgOH tube gels led to the detection of at least five translationally active human IFN-beta mRNA species. The results obtained are consistent with the existence of IFN-beta genes on different human chromosomes. Marked cell-dependent variability in the expression of these IFN mRNA species was observed.

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