The influence of inhibitors of RNA and protein synthesis on dexamethasone action in carrageenin paw edema and adjuvant arthritis of rats
- PMID: 6180613
Item in Clipboard
The influence of inhibitors of RNA and protein synthesis on dexamethasone action in carrageenin paw edema and adjuvant arthritis of rats
Agents Actions Suppl.
1982.
Abstract
The anti-inflammatory effect of dexamethasone in carrageenin paw edema and in adjuvant arthritis of rats was not influenced by simultaneous injection of RNA/protein synthesis inhibitors. The increase of the plasma alpha 2-microglobulin level during adjuvant arthritis was significantly reduced after administration of RNA/protein synthesis inhibitors. This inhibitory effect was abolished by simultaneous dexamethasone treatment. The present results do hardly support the hypothesis that the anti-inflammatory activity of dexamethasone and other glucocorticosteroids in carrageenin edema and adjuvant arthritis of rats might be mediated by de novo protein synthesis.
Similar articles
-
Problems and results in testing the possible mode of anti-inflammatory glucocorticoid action in carrageenin rat paw oedema: advantages of local substance injection.Int J Tissue React. 1984;6(6):471-5. Int J Tissue React. 1984. PMID: 6530351
-
Anti-inflammatory activity of catalase in carrageenin edema, manganese chloride edema and adjuvant arthritis of rats.Agents Actions Suppl. 1982;10:157-72. Agents Actions Suppl. 1982. PMID: 6956216 No abstract available.
-
Nonspecific action of glucocorticosteroids after high-dose pulse therapy?Agents Actions. 1990 Aug;31(1-2):148-51. doi: 10.1007/BF02003235. Agents Actions. 1990. PMID: 2285020
-
The involvement of RNA synthesis and cyclic AMP in the activation of fat cell lipolysis by growth hormone and glucocorticoids.Horm Metab Res. 1970;2:Suppl 2:20-7. Horm Metab Res. 1970. PMID: 4340424 Review. No abstract available.
-
[Trace phenomena in the functional dynamics of protein synthesis].Zh Vyssh Nerv Deiat Im I P Pavlova. 1973 Mar-Apr;23(2):323-30. Zh Vyssh Nerv Deiat Im I P Pavlova. 1973. PMID: 4589279 Review. Russian. No abstract available.
Cited by
-
The rat C-reactive protein--isolation and response to experimental inflammation and tissue damage.Agents Actions. 1987 Jun;21(1-2):93-7. doi: 10.1007/BF01974928. Agents Actions. 1987. PMID: 3630861
-
Problems and results in testing the possible general mode of action of glucocorticoids in rat adjuvant arthritis.Agents Actions. 1986 Jan;17(3-4):325-6. doi: 10.1007/BF01982636. Agents Actions. 1986. PMID: 3962778
-
Acute phase reaction in rats: independent change of acute phase protein plasma concentration and macroscopic inflammation in primary rat adjuvant inflammation.Agents Actions. 1990 Jun;30(3-4):412-7. doi: 10.1007/BF01966306. Agents Actions. 1990. PMID: 1696777
-
In vivo effect of ticlopidine on fibrinogen-platelet cofactor activity and binding of fibrinogen to platelets.Agents Actions Suppl. 1984;15:97-104. doi: 10.1007/BF01966985. Agents Actions Suppl. 1984. PMID: 6091425 No abstract available.
MeSH terms
Substances
LinkOut - more resources
Medical