doi: 10.1099/00221287-128-4-875.
The mode of action of berninamycin and mechanism of resistance in the producing organism, Streptomyces bernensis
- PMID: 6181185
- DOI: 10.1099/00221287-128-4-875
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The mode of action of berninamycin and mechanism of resistance in the producing organism, Streptomyces bernensis
J Gen Microbiol.
1982 Apr.
Abstract
The mode of action of berninamycin on bacterial protein synthesis is related to that of thiostrepton, a dissimilar compound. Both antibiotics bind to the complex of 23S RNA with protein L11 and both affect various functions of the ribosomal A site. Also, Streptomyces bernensis and Streptomyces azureus (which, respectively, produce berninamycin and thiostrepton) possess similar ribosomal RNA methylases capable of rendering ribosomes resistant to these compounds. Resistance involves specific pentose-methylation of 23S ribosomal RNA.
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