Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Apr;128(4):875-84.
doi: 10.1099/00221287-128-4-875.

The mode of action of berninamycin and mechanism of resistance in the producing organism, Streptomyces bernensis

J Thompson, E Cundliffe, M J Stark

The mode of action of berninamycin and mechanism of resistance in the producing organism, Streptomyces bernensis

J Thompson et al. J Gen Microbiol. 1982 Apr.

Abstract

The mode of action of berninamycin on bacterial protein synthesis is related to that of thiostrepton, a dissimilar compound. Both antibiotics bind to the complex of 23S RNA with protein L11 and both affect various functions of the ribosomal A site. Also, Streptomyces bernensis and Streptomyces azureus (which, respectively, produce berninamycin and thiostrepton) possess similar ribosomal RNA methylases capable of rendering ribosomes resistant to these compounds. Resistance involves specific pentose-methylation of 23S ribosomal RNA.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources