Tapping the immunological repertoire to produce antibodies of predetermined specificity

Abstract

We understand the structure of antibodies in detail, but know little about the molecular basis of the immunogenicity of proteins. Recent experiments have shown that chemically synthesized peptides representative of virtually any part of the surface of a protein can elicit antibodies reactive with the native molecule. Such peptides can serve as synthetic vaccines, and antibodies, useful in the study of changes in protein structure, can be generated. As these antibodies react with regions of the protein known in advance to the experimenter, they can be said to be of predetermined specificity.