[Inhibitor of the action of swine leukocyte interferon]

Abstract

Studies on the antagonists of interferon effect ("stimulon", "TAI", "blocker", "antiinterferon") formed under the influence of viruses and mitogens as well as those found in noninfected tissues deal largely with their blocking effect on the antiviral activity of interferon. Previously we had found an inhibitor of antiviral effect in preparations of human cadaverous and swine leukocyte interferons. This paper presents the results of studies on some physico-chemical properties of an inhibitor of the effect of swine leukocyte interferon and its antiproliferative activity. The inhibitor is resistant to the effect of nucleases and lyophilization, manifests limited heterospecificity towards interferons and cell cultures, has marked antiproliferative activity in different cell cultures including those of tumor origin.