doi: 10.1016/0092-8674(76)90115-x.
Cell surface protein decreases microvilli and ruffles on transformed mouse and chick cells
- PMID: 61821
- DOI: 10.1016/0092-8674(76)90115-x
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Cell surface protein decreases microvilli and ruffles on transformed mouse and chick cells
Cell.
1976 Oct.
Abstract
Transformation of cultured fibroblasts usually results in a decrease in a high molecular weight cell surface glycoprotein (LETS protein) and often in increased numbers of surface microvilli and ruffles. We have isolated such a major cell surface glycoprotein from chick embryo fibroblasts; this protein, CSP, is decreased after transformation. Treatment of a mouse tumor cell line (SV1), L929 cells, and transformed chick fibroblasts with CSP results in a decrease in the number of microvilli and marginal ruffles, accompanied by restoration of a more normal morphology.
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