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. 1982 Oct 28;299(5886):793-7.
doi: 10.1038/299793a0.

Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

M Noda, H Takahashi, T Tanabe, M Toyosato, Y Furutani, T Hirose, M Asai, S Inayama, T Miyata, S Numa

Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

M Noda et al. Nature. .

Abstract

DNA sequences complementary to the Torpedo californica electroplax mRNA coding for the alpha-subunit precursor of the acetylcholine receptor were cloned. The nucleotide sequence of the cloned cDNA indicates that the precursor consists of 461 amino acids including a prepeptide of 24 amino acids. Possible sites for acetylcholine binding and antigenic determinants on the alpha-subunit molecule are discussed.

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