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Comparative Study
. 1982 Jul;12(3):263-7.
doi: 10.1007/BF01965386.

A species comparison of the histamine H2-receptor on mast cells and basophils

T J Rising, S Lewis
Comparative Study

A species comparison of the histamine H2-receptor on mast cells and basophils

T J Rising et al. Agents Actions. 1982 Jul.

Abstract

The histamine H2-agonist dimaprit was employed in experiments to investigate the role of H2-receptors in mediator release systems from the rat, guinea-pig and man. Whereas inhibition of histamine release by dimaprit was observed in all 3 species, this effect appeared not always to be related to H2-receptor occupancy. Although the data in general support previous evidence for the presence of H2-receptors on human basophils and guinea-pig mast cells, the use of dimaprit as a pure H2-agonist in these studies is questioned. No evidence for H2-receptors on rat mast cells was obtained.

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References

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