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. 1982 Jul;12(3):333-9.
doi: 10.1007/BF01965399.

Inflammation, counter irritation and rat serum acute phase alpha 2-macroglobulin levels

B A Baldo

Inflammation, counter irritation and rat serum acute phase alpha 2-macroglobulin levels

B A Baldo. Agents Actions. 1982 Jul.

Abstract

Following the injection of turpentine and carrageenan into rats, laboratory models for counter irritation were assessed by measuring changes in paw thicknesses and serum acute phase alpha 2-macroglobulin concentrations. Both indices of inflammation were also examined in groups of rats dosed with 6-mercaptopurine, the best inhibitor found so far of elevated levels of alpha 2-macroglobulin in rat serum. Results showed that there is no relationship between the degree of irritant-induced inhibition of inflammation and the serum concentration of the acute phase protein. Hence, at least in the models for counter irritation used in this study, alpha 2-macroglobulin cannot be viewed as an endogenous anti-inflammatory protein.

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