doi: 10.1016/0006-8993(82)90969-6.
Regulation of substance P by nerve growth factor: disruption by capsaicin
- PMID: 6182949
- DOI: 10.1016/0006-8993(82)90969-6
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Regulation of substance P by nerve growth factor: disruption by capsaicin
Brain Res.
.
Abstract
Capsaicin depleted substance P from guinea pig dorsal root ganglia and inhibited the retrograde axoplasmic transport of nerve growth factor (NGF). Doses of capsaicin which depleted substance P also inhibited the retrograde axoplasmic transport of NGF. Inhibition of the retrograde transport of NGF by capsaicin preceded substance P depletion. Supplementation of guinea pigs with mouse NGF completely prevented capsaicin-induced substance P depletion. It is concluded that capsaicin depletes substance P from primary afferent neurons of the adult guinea pig by altering the availability of NGF. The data support a role for NGF in the normal maintenance of neuropeptide levels in some sensory neurons in the adult animal.
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