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. 1982;18(4):209-13.
doi: 10.1159/000149327.

Immunogenicity of conjugates and micelles of synthetic hepatitis B surface antigen peptides

Y Sanchez, I I Ionescu-Matiu, J T Sparrow, J L Melnick, G R Dreesman

Immunogenicity of conjugates and micelles of synthetic hepatitis B surface antigen peptides

Y Sanchez et al. Intervirology. 1982.

Abstract

A cyclic peptide containing the amino acid sequence 122 through 137 of the major hepatitis B surface antigen (HBsAg) polypeptide was synthesized. The immunogenicity of this synthetic peptide, aggregated in micelles or covalently coupled to tetanus toxoid, was assessed in mice. Antibodies against HBsAg (anti-HBs) were obtained with both preparations, administered either in saline suspension or adsorbed on aluminum gel. The peptide-tetanus toxoid conjugate was more immunogenic than the peptide micelles, producing high levels of specific anti-HBs.

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