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. 1982 Sep 20;32(1):69-74.
doi: 10.1016/0304-3940(82)90231-2.

Evidence for the involvement of substance P in the atropine-resistant peristalsis of the guinea-pig ileum

L Barthó, P Holzer, J Donnerer, F Lembeck

Evidence for the involvement of substance P in the atropine-resistant peristalsis of the guinea-pig ileum

L Barthó et al. Neurosci Lett. .

Abstract

In the isolated, vascularly perfused guinea-pig ileum, peristalsis could be induced by raising the intraluminal pressure in the presence of atropine. Atropine-resistant peristalsis was greatly inhibited or abolished by the substance P antagonist (D-Pro2, D-Trp7.9)-substance P, substance P desensitization, hexamethonium and by the enkephalin analogue FK 33-824. It is concluded that substance P neurones of the intestine play an important role in the atropine-resistant peristalsis of the guinea-pig ileum.

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