Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Jan;48(1):87-92.

The interchange of derivatives of human B2-microglobulin in HLA alloantigens

P J Ward, A R Sanderson

The interchange of derivatives of human B2-microglobulin in HLA alloantigens

P J Ward et al. Immunology. 1983 Jan.

Abstract

Derivatives of human Beta 2 microglobulin (B2M) have been made by attaching various groups to amino groups in the peptide. In this way 125iodine, dinitrobenzyl, and m-maleimidobenzoyl groups have been introduced. These derivatives of B2M were able to associate with HLA chains and could be displaced again by native B2M. The rate of dissociation of HLA chains and derivatives of B2M is comparable with the intrinsically labelled native dimer. In some cases, particularly with [125I]-B2M, the rate of dissociation appears to be smaller than for native B2M.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Biol Chem. 1968 Aug 10;243(15):4095-103 - PubMed
    1. Nature. 1968 Oct 12;220(5163):192-5 - PubMed
    1. Anal Biochem. 1968 Oct 24;25(1):192-205 - PubMed
    1. Proc Natl Acad Sci U S A. 1972 Oct;69(10):2914-7 - PubMed
    1. Nature. 1975 Mar 20;254(5497):267-9 - PubMed

LinkOut - more resources