Review
[Substance P - a neuropeptide transmitter]
[Article in
German]
- PMID: 6184894
Item in Clipboard
Review
[Substance P - a neuropeptide transmitter]
[Article in
German]
Z Gesamte Inn Med.
.
Abstract
a survey is given concerning the effects of undecapeptide Substance P (SP). SP is a peptide with eleven amino acids. It is localized in the nervous system and out of it. SP seems to play an important physiological role in neuronal functions, blood pressure, secretion and smooth muscle activity. In these functions SP has a dual action. From this dual action it is concluded that SP acts as modulatory or regulatory peptide. The regulatory function of SP seems to be connected with the system of endogenous opiates and with the system of catecholamines. The changes of application of SP in practice are unknown up to now.
Similar articles
-
Substance P: its distribution, pharmacological actions and possible physiological role in sensory neurons.Clin Physiol. 1981 Jun;1(3):235-51. doi: 10.1111/j.1475-097x.1981.tb00892.x. Clin Physiol. 1981. PMID: 6175470
-
Tachykinins and calcitonin gene-related peptide in relation to peripheral functions of capsaicin-sensitive sensory neurons.Acta Physiol Scand Suppl. 1986;551:1-45. Acta Physiol Scand Suppl. 1986. PMID: 2430427
-
Leukotriene D4 acts in part to contract guinea pig ileum smooth muscle by releasing substance P.J Pharmacol Exp Ther. 1987 Feb;240(2):523-8. J Pharmacol Exp Ther. 1987. PMID: 2433430
-
Substance P and primary afferent transmission.Adv Biochem Psychopharmacol. 1976;15:187-91. Adv Biochem Psychopharmacol. 1976. PMID: 192049 Review.
-
Substance P: pharmacology, properties, and mode of action.Vopr Biokhim Mozga. 1978;13:168-76. Vopr Biokhim Mozga. 1978. PMID: 388854 Review. No abstract available.
Cited by
-
Evaluation of Substance P as a New Stress Parameter in Horses in a Stress Model Involving Four Different Stress Levels.Animals (Basel). 2023 Mar 24;13(7):1142. doi: 10.3390/ani13071142. Animals (Basel). 2023. PMID: 37048398 Free PMC article.