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. 1982 Nov;22(5):824-31.
doi: 10.1128/AAC.22.5.824.

7-Hydroxytropolone: an inhibitor of aminoglycoside-2"-O-adenylyltransferase

N E Allen, W E Alborn Jr, J N Hobbs Jr, H A Kirst

7-Hydroxytropolone: an inhibitor of aminoglycoside-2"-O-adenylyltransferase

N E Allen et al. Antimicrob Agents Chemother. 1982 Nov.

Abstract

Aminoglycoside-2"-O-adenylyltransferase was inhibited by 7-hydroxytropolone. Inhibition was competitive with respect to the cosubstrate ATP and appeared to require the unique vicinal arrangement of oxygens found in 7-hydroxytropolone. Combinations of 7-hydroxytropolone plus the appropriate aminoglycoside substrates were active against resistant bacteria possessing the adenylyltransferase. No potentiation was observed against other aminoglycoside-resistant or -susceptible strains. The fact that the inhibition of an aminoglycoside-modifying enzyme overcomes the poor uptake of aminoglycosides in resistant strains points to the singular importance of the inactivating enzyme as a determinant of resistance.

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References

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