Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1976 Nov;41(5):501-12.
doi: 10.1016/0013-4694(76)90062-6.

Conditioned EEG desynchronization and seizure occurrence in patients

A R Wyler, J S Lockard, A A Ward Jr, C A Finch
Clinical Trial

Conditioned EEG desynchronization and seizure occurrence in patients

A R Wyler et al. Electroencephalogr Clin Neurophysiol. 1976 Nov.

Abstract

Five patients with seizures poorly controlled by standard anticonvulsant medication, underwent EEG operant conditioning. The operant paradigm reinforced the production of low voltage fast activity while decreasing frequencies below 10 c/sec. Seizure frequency decreased in 2 patients, seizure severity was attenuated in 2 others, and one patient who was only given reinforecement for scalp EMG suppression whowed no change in seizure parameters. Pseudoconditioning and control periods ruled out placebo effects. A rationale for this phenomenon is proposed.

PubMed Disclaimer

LinkOut - more resources