doi: 10.1084/jem.157.2.795.
Fine specificity of idiotope suppression in the A/J anti-azophenylarsonate response
- PMID: 6185619
- PMCID: PMC2186940
- DOI: 10.1084/jem.157.2.795
Item in Clipboard
Fine specificity of idiotope suppression in the A/J anti-azophenylarsonate response
J Exp Med.
.
Abstract
Two hapten-inhibitable murine monoclonal antiidiotopic antibodies identified two idiotopes expressed by the heavy chain of hybridoma protein 36-65, whose amino acid sequence is encoded in the germ line of A/J mice. Among cross-reactive idiotype-positive hybridoma proteins and p-azophenylarsonate-immune antibodies, the two idiotopes were not always expressed together; some diversified antibodies expressed one idiotope without the other. Suppression that was induced by the two antiidiotopes was idiotope specific and corresponded to the fine specificities of these two reagents.
Similar articles
-
Idiotypic heterogeneity of the cross-reactive idiotype associated with the anti-p-azophenylarsonate antibodies of BALB/c mice.J Immunol. 1983 Jul;131(1):423-8. J Immunol. 1983. PMID: 6190919
-
Complete amino acid sequence of heavy chain variable regions derived from two monoclonal anti-p-azophenylarsonate antibodies of BALB/c mice expressing the major cross-reactive idiotype of the A/J strain.J Exp Med. 1984 Oct 1;160(4):1070-86. doi: 10.1084/jem.160.4.1070. J Exp Med. 1984. PMID: 6207261 Free PMC article.
-
Idiotype connectance in the immune system. I. Expression of a cross-reactive idiotype on induced anti-p-azophenylarsonate antibodies and on endogenous antibodies not specific for arsonate.J Exp Med. 1983 Apr 1;157(4):1116-36. doi: 10.1084/jem.157.4.1116. J Exp Med. 1983. PMID: 6403653 Free PMC article.
-
Regulation of immunity to the azobenzenearsonate hapten.Adv Immunol. 1982;32:253-300. doi: 10.1016/s0065-2776(08)60723-3. Adv Immunol. 1982. PMID: 6214163 Review. No abstract available.
-
Studies of genetic control and microheterogeneity of an idiotype associated with anti-P-azophenylarsonate antibodies of A/J mice.Prog Clin Biol Res. 1980;42:231-47. Prog Clin Biol Res. 1980. PMID: 6994110 Review. No abstract available.
Cited by
-
Induction of idiotope suppression in the anti-azophenylarsonate response of T-depleted A/J mice.J Exp Med. 1984 Apr 1;159(4):1283-8. doi: 10.1084/jem.159.4.1283. J Exp Med. 1984. PMID: 6608575 Free PMC article.
-
Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice.Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10321-5. doi: 10.1073/pnas.89.21.10321. Proc Natl Acad Sci U S A. 1992. PMID: 1438216 Free PMC article.
-
Activation specificity of arsonate-reactive T cell clones. Structural requirements for hapten recognition and comparison with monoclonal antibodies.J Exp Med. 1984 Feb 1;159(2):479-94. doi: 10.1084/jem.159.2.479. J Exp Med. 1984. PMID: 6198431 Free PMC article.
-
Human neutrophil-mediated nonoxidative antifungal activity against Cryptococcus neoformans.Infect Immun. 2000 Nov;68(11):6257-64. doi: 10.1128/IAI.68.11.6257-6264.2000. Infect Immun. 2000. PMID: 11035733 Free PMC article.
-
Lysis of inducer T cell clones by activated macrophages and macrophage-like cell lines.J Exp Med. 1983 Oct 1;158(4):1243-58. doi: 10.1084/jem.158.4.1243. J Exp Med. 1983. PMID: 6194244 Free PMC article.
