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. 1982 Nov 25;10(22):7387-93.
doi: 10.1093/nar/10.22.7387.

Avian myeloblastosis reverse transcriptase deacylates tryptophanyl-tRNA

L Sarih, M Fournier, F von der Haar, J Labouesse, S Litvak
Free PMC article

Avian myeloblastosis reverse transcriptase deacylates tryptophanyl-tRNA

L Sarih et al. Nucleic Acids Res. .
Free PMC article

Abstract

Tryptophanyl-tRNA can be used as a primer for RNA-dependent DNA synthesis by avian reverse transcriptase. We have determined that whereas the retroviral polymerase is not by itself capable of deacylating Trp-tRNATrp, the ester linkage between the 3' OH of the ribose moiety and the aminoacid can be very efficiently hydrolyzed when both the polymerase and the viral 35 S RNA are present.

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