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Comparative Study
. 1982 Dec;5(4):259-68.
doi: 10.1016/0198-8859(82)90018-0.

Subtypes of HLA-B27 detected by cytotoxic T lymphocytes and their role in self-recognition

M H Breuning, C J Lucas, B S Breur, M Y Engelsma, G G de Lange, A J Dekker, W E Biddison, P Ivanyi
Comparative Study

Subtypes of HLA-B27 detected by cytotoxic T lymphocytes and their role in self-recognition

M H Breuning et al. Hum Immunol. 1982 Dec.

Abstract

In the present study cytotoxic T lymphocytes were generated in MLC of lymphocytes from two unrelated HLA-A, B, C-identical, B27-positive, but D/DR-different, individuals. These CTL were shown to detect subtypes of HLA-B27. CTL specific for influenza virus lysed infected target cells matched for HLA-B27 only when they shared the same subtype. This indicates that the two subtypes of HLA-B27 detected by CTL function also as distinct elements in a self-restricted CTL response. Both subtypes were found among patients with ankylosing spondylitis.

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