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Case Reports
. 1981;226(2):131-5.
doi: 10.1007/BF00313441.

Unusual 'spike-wave stupor' in a patient with manic-depressive psychosis treated with amitriptyline

E Rumpl, H Hinterhuber
Case Reports

Unusual 'spike-wave stupor' in a patient with manic-depressive psychosis treated with amitriptyline

E Rumpl et al. J Neurol. 1981.

Abstract

'Spike-wave stupor' was observed in a 58-year-old male patient with manic-depressive psychosis. Almost continuous atypical spike-wave activity was seen in conjunction with a stuporous episode with stereotyped automatism. Intravenous diazepam ended both the electroencephalographic epileptiform discharges and the clinical stupor. Before and during this episode the patient was treated with an average-dose amitriptyline monotherapy. There was no family history of epileptic seizures. The patient had had electroconvulsive therapy. The history suggests that the analeptic property of amitriptyline induced the 'spike-wave stupor' in this patient.

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