doi: 10.1016/0027-5107(83)90080-5.
Induction of chromosome aberrations by chemical mutagens in neural ganglia of Drosophila melanogaster
- PMID: 6186912
- DOI: 10.1016/0027-5107(83)90080-5
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Induction of chromosome aberrations by chemical mutagens in neural ganglia of Drosophila melanogaster
Mutat Res.
1983 Jan.
Abstract
Chromatid aberrations induced by various concentrations of bleomycin, cyclophosphamide and mitomycin C were analyzed in neural ganglia of third-instar larvae of Drosophila melanogaster. A clear dose response was observed with increasing dose after treatment with bleomycin and mitomycin C, whereas no effect was observed after treatment with cyclophosphamide. A comparison with published data for the induction of sex-linked recessive lethals showed that, at least for the 3 drugs tested, the use of both tests eliminates false negatives and might comprise a useful procedure for testing mutagenicity in Drosophila.
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