doi: 10.1002/eji.1830050712.
Immune response to phosphorylcholine. I. Characterization of the epitope-specific antibody
- PMID: 61872
- DOI: 10.1002/eji.1830050712
Item in Clipboard
Immune response to phosphorylcholine. I. Characterization of the epitope-specific antibody
Eur J Immunol.
1976 Jul.
Abstract
The antibodies to phosphorylcholine induced in BALB/c mice were isolated and studied with a variety of biochemical and immunochemical methods. Analysis of the idiotype and the hapten-binding specificities showed no differences to the phosphorylcholine-binding myeloma protein TEPC 15, indicating a high degree of homogeneity. However, disc electrophoresis, isoelectric focusing and amino acid composition data indicated large differences in the structure of anti-phosphorylcholine antibody and TEPC 15. By these criteria the anti-phosphorylcholine antibodies from BALB/c mice are of oligoclonal origin.
Similar articles
-
Uniformity in the clonal repertoire for the immune response to phosphorylcholine in mice.Eur J Immunol. 1976 Oct;6(10):669-74. doi: 10.1002/eji.1830061002. Eur J Immunol. 1976. PMID: 65140
-
A phosphorylcholine idiotype related to TEPC 15 in mice infected with Ascaris suum.J Immunol. 1976 Apr;116(4):1105-9. J Immunol. 1976. PMID: 1254963
-
Clonal nature of the immune response to phosphocholine. VI. Molecular uniformity of a single idiotype among BALB/c mice.J Immunol. 1978 Oct;121(4):1410-5. J Immunol. 1978. PMID: 701802
-
The response to phosphorylcholine: dissecting an immune response.Transplant Rev. 1975;27:24-56. Transplant Rev. 1975. PMID: 52926 Review. No abstract available.
-
Antigen-binding myeloma proteins of mice.Adv Immunol. 1977;25:141-211. Adv Immunol. 1977. PMID: 76433 Review. No abstract available.
Cited by
-
Expression of equivalent clonotypes in BALB/c and A/J mice after immunization with phosphorylcholine.J Exp Med. 1976 Nov 2;144(5):1294-304. doi: 10.1084/jem.144.5.1294. J Exp Med. 1976. PMID: 62819 Free PMC article.
-
Demonstration of an idiotypic antigen on a monoclonal cold agglutinin and on its isolated heavy and light chains.Proc Natl Acad Sci U S A. 1976 May;73(5):1702-6. doi: 10.1073/pnas.73.5.1702. Proc Natl Acad Sci U S A. 1976. PMID: 58418 Free PMC article.
-
Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations.EMBO J. 1995 Jun 15;14(12):2784-94. doi: 10.1002/j.1460-2075.1995.tb07278.x. EMBO J. 1995. PMID: 7796805 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
