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. 1978 Jan 1;47(1):125-7.
doi: 10.1016/0014-2999(78)90383-7.

Imipramine antagonism of apomorphine-induced hypothermia: a non-dopaminergic interaction

A J Puech, H Francès, P Simon

Imipramine antagonism of apomorphine-induced hypothermia: a non-dopaminergic interaction

A J Puech et al. Eur J Pharmacol. .

Abstract

Imipramine antagonized high dose apomorphine-induced hypothermia, and did not modify small dose apomorphine-induced hypothermia. It is suggested that apomorphine-induced hypothermia is the result of two effects. The first, induced by small doses of apomorphine, and antagonized by pimozide and sulpiride, is probably related to dopaminergic receptor stimulation. The second, induced by high doses of apomorphine, and antagonized by imipramine, is probably not related to dopaminergic receptor stimulation.

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