doi: 10.1002/eji.1830060808.
Expression of Ia determinants on immunocompetent cells
- PMID: 61879
- DOI: 10.1002/eji.1830060808
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Expression of Ia determinants on immunocompetent cells
Eur J Immunol.
1976 Aug.
Abstract
The expression of Ia (immune response region-associated) antigens on the surface of lymphocyte subpopulations with defined immunological function has been investigated by negative selection of subpopulations with anti-Ia sera and complement. Ia determinants were found on both unprimed (IgM) and on primed (IgG) antibody-forming precursor cells. No Ia antigens were detected on the surface of helper T cells. In contrast, suppressor T cells were sensitive to treatment with anti-Ia sera and complement demonstrating the presence of Ia determinants on this T cell subpopulation.
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