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. 1983 Mar;45(3):1190-4.
doi: 10.1128/JVI.45.3.1190-1194.1983.

Isolation and partial characterization of a monoclonal antibody to the Rous sarcoma virus transforming protein pp60src

S J Parsons, D J McCarley, C M Ely, D C Benjamin, J T Parsons

Isolation and partial characterization of a monoclonal antibody to the Rous sarcoma virus transforming protein pp60src

S J Parsons et al. J Virol. 1983 Mar.

Abstract

Transformation of cells by Rous sarcoma virus is mediated by the product of the viral src gene, pp60src. A hybridoma cell line producing an immunoglobulin G3 antibody to pp60src was isolated after lymph node cells from immune mice were fused with mouse myeloma cells (P3-NS1-1). Mice were immunized with p60src purified from Escherichia coli cells expressing the src gene product. The monoclonal antibody immunoprecipitated pp60src from Rous sarcoma virus-transformed cells and recognized an antigenic determinant located in the amino-terminal third of the pp60src protein.

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