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. 1983;17(5):475-84.
doi: 10.1007/BF00696871.

Biochemical characterization of Ia antigens encoded by the RT1.B and RT1.D loci in the rat MHC

E P Blankenhorn, F W Symington, D V Cramer

Biochemical characterization of Ia antigens encoded by the RT1.B and RT1.D loci in the rat MHC

E P Blankenhorn et al. Immunogenetics. 1983.

Abstract

Ia antigens in rats are genetically associated with typical MHC-linked immune response (Ir) genes. One rat Ir gene (IR-GLT) has recently been mapped to the RT1.D locus in a rat MHC recombinant, WRC. We have studied the expression of Ia antigenic determinants in WRC and its parental strains BN and WRA using a panel of monoclonal antibodies. Our results suggest that the inheritance of IR-GLT corresponds with the inheritance of I-E-like, but not I-A-like, antigens in the WRC rat. These observations were confirmed when WRC I-E-like antigens were analyzed by two-dimensional gel electrophoresis. We propose that RT1.D shares both functional and antigenic homologies with the mouse I-E subregion.

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References

    1. Lancet. 1975 Jun 28;1(7922):1406-9 - PubMed
    1. Immunol Rev. 1981;60:59-83 - PubMed
    1. J Exp Med. 1978 Oct 1;148(4):925-39 - PubMed
    1. Immunogenetics. 1981;14(1-2):53-61 - PubMed
    1. J Exp Med. 1980 May 1;151(5):1139-50 - PubMed

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