doi: 10.1083/jcb.76.1.175.
Lens differentiation. Crystallin synthesis in isolated epithelia from calf lenses
- PMID: 618891
- PMCID: PMC2109957
- DOI: 10.1083/jcb.76.1.175
Item in Clipboard
Lens differentiation. Crystallin synthesis in isolated epithelia from calf lenses
J Cell Biol.
1978 Jan.
Abstract
In the calf eye lens, four morphologically distinct cell types can be detected: three in the epithelial monolayer and one in the cortical part. During differentiation, there is a quantitative change in the synthesis of crystallin subunits. A marked increase in alphaA-chains and several beta-crystallin polypeptides accompanies the transition from epithelial to fiberlike lens cells while synthesis of the non-crystallin proteins diminishes significantly.
Similar articles
-
State of differentiation of bovine epithelial lens cells in vitro. Modulation of the synthesis and of the polymerization of specific proteins (crystallins) and non-specific proteins in relation to cell divisions.Exp Cell Res. 1983 May;145(2):433-46. doi: 10.1016/0014-4827(83)90022-8. Exp Cell Res. 1983. PMID: 6407854
-
Expression and regulation of alpha-, beta-, and gamma-crystallins in mammalian lens epithelial cells.Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3608-19. doi: 10.1167/iovs.04-0423. Invest Ophthalmol Vis Sci. 2004. PMID: 15452068
-
[The synthesis and localization of crystallins in different cell compartments of the crystalline lens in adult frogs: immunoautoradiographic and immunofluorescent research].Ontogenez. 1991 Jul-Aug;22(4):381-93. Ontogenez. 1991. PMID: 1945270 Russian.
-
[The crystalline lens as a model for studying the cellular and molecular mechanisms of differentiation in the adult organism].Ontogenez. 1993 May-Jun;24(3):41-52. Ontogenez. 1993. PMID: 8355959 Review. Russian.
-
Structure and function of α-crystallins: Traversing from in vitro to in vivo.Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):149-66. doi: 10.1016/j.bbagen.2015.06.008. Epub 2015 Jun 25. Biochim Biophys Acta. 2016. PMID: 26116912 Review.
Cited by
-
Expression of the murine alpha B-crystallin gene is not restricted to the lens.Mol Cell Biol. 1989 Mar;9(3):1083-91. doi: 10.1128/mcb.9.3.1083-1091.1989. Mol Cell Biol. 1989. PMID: 2725488 Free PMC article.
-
Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens.BMC Ophthalmol. 2003 Jan 24;3:3. doi: 10.1186/1471-2415-3-3. BMC Ophthalmol. 2003. PMID: 12546709 Free PMC article.
-
Human hair follicle cells in culture: the development of a new culture system and its potential applications.Mol Biol Rep. 1986;11(1):3-12. doi: 10.1007/BF00417588. Mol Biol Rep. 1986. PMID: 3511359 Review. No abstract available.
