Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Feb;80(4):1083-6.
doi: 10.1073/pnas.80.4.1083.

Interferon-mediated inhibition of virus penetration

P A Whitaker-Dowling, D K Wilcox, C C Widnell, J S Youngner

Interferon-mediated inhibition of virus penetration

P A Whitaker-Dowling et al. Proc Natl Acad Sci U S A. 1983 Feb.

Abstract

Pretreatment of mouse L cells with mouse interferon (IFN) inhibits the penetration of vesicular stomatitis virus without affecting viral adsorption. The inhibition of virus uptake by IFN is dose dependent and, at the highest dose tested (1,000 units/ml), reaches 65%; 24 hr of treatment with IFN are required for maximal effect. A similar inhibition of uptake of virus occurs in human diploid fibroblasts and primary chicken embryo fibroblasts treated with homologous IFN. No significant inhibition occurs when cells are treated with heterologous IFN. These results document a previously unrecognized antiviral effect of IFN--namely, inhibition at the level of viral uptake.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Virol. 1975 Jun;15(6):1348-56 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3542-4 - PubMed
    1. Proc Soc Exp Biol Med. 1961 Jul;107:639-44 - PubMed
    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Virology. 1969 Feb;37(2):285-90 - PubMed

Publication types

LinkOut - more resources