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. 1983 May;80(9):2618-22.
doi: 10.1073/pnas.80.9.2618.

Coexpression of keratin- and vimentin-type intermediate filaments in human metastatic carcinoma cells

F C Ramaekers, D Haag, A Kant, O Moesker, P H Jap, G P Vooijs

Coexpression of keratin- and vimentin-type intermediate filaments in human metastatic carcinoma cells

F C Ramaekers et al. Proc Natl Acad Sci U S A. 1983 May.

Abstract

Metastatic tumor cells of epithelial origin present in effusions from human serous cavity fluids (ascites or pleural fluid) were examined for their intermediate-sized filament types by using antibodies to keratin, vimentin, and desmin in the indirect immunofluorescence technique. Solid epithelial tumors (both primary carcinomas and their metastases) contain keratin intermediate-sized filaments exclusively. However, when these cells are present in ascitic or pleural fluid, they also express vimentin, which occurs in a fibrillar organization. The possible effects of this additional, but temporary, cytoskeleton on metastatic growth or aggressiveness (or both) are discussed.

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References

    1. Proc Natl Acad Sci U S A. 1977 Jun;74(6):2490-4 - PubMed
    1. J Cell Biol. 1980 Mar;84(3):633-54 - PubMed
    1. Nature. 1978 Mar 9;272(5649):175-7 - PubMed
    1. Cytobiologie. 1978 Aug;17(2):365-91 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4364-8 - PubMed

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