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. 1983 Mar;21(3):254-7.
doi: 10.1111/j.1399-3011.1983.tb03102.x.

Synthesis and biological activity of glycosylated analogs of the C-terminal hexapeptide and heptapeptide of substance P

C Poujade, S Lavielle, Y Torrens, A Marquet

Synthesis and biological activity of glycosylated analogs of the C-terminal hexapeptide and heptapeptide of substance P

C Poujade et al. Int J Pept Protein Res. 1983 Mar.

Abstract

The synthesis of two glycosylated analogs of Substance P is described. The activity of the peptides was assayed on the isolated guinea-pig ileum and their degradation was studied using rat hypothalamus slices. While glycosylation noticeably enhances the solubility of the corresponding compounds, the beta-glucopyranosyl moiety only slightly modifies the biological half-life and the bioactivity of the glycopeptides.

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