Effects of chlordecone and mirex on amino acids incorporation into brain and liver proteins in the mouse

Abstract

Effects of chlordecone and mirex on 3H-leucine or 3H-amino acids incorporation into mouse brain and liver proteins were investigated. In mice treated with chlordecone by oral intubation, 25 mg/kg/day for 3 days, a significant decrease in 3H-leucine incorporation into brain trichloroacetic acid (TCA)-precipitable proteins was observed. On the other hand, mirex significantly increased 3H-leucine incorporation into TCA-precipitable proteins in the liver but not in that of the brain. These phenomena also were confirmed by the data obtained from 3H-amino acids mixture incorporation into both brain and liver proteins in mice which were orally administered with chlordecone or mirex, 25 mg/kg/day for 4 days. These results are also substantiated by a single dose of chlordecone (125 or 200 mg/kg, p.o.) or mirex (250 or 350 mg/kg, p.o.). These results suggest that although structurally similar, these two analogs differ significantly in their effects on amino acids incorporation into brain and liver proteins.