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Comparative Study
. 1983 Jan-Feb;134C(1):159-64.
doi: 10.1016/s0769-2625(83)80159-7.

Effects of various coryneforms on mononuclear phagocyte system function and on production of tumour necrosis factor in mice

N Bloksma, R de Leeuw, F M Hofhuis, N A Westerdaal, B Benaissa-Trouw, J M Willers
Comparative Study

Effects of various coryneforms on mononuclear phagocyte system function and on production of tumour necrosis factor in mice

N Bloksma et al. Ann Immunol (Paris). 1983 Jan-Feb.

Abstract

Vaccines of 6 strains of the genera Corynebacterium and Propionibacterium were tested for induction of hepatosplenomegaly and stimulation of clearance of injected colloidal carbon and viable Listeria monocytogenes. These effects were compared with the ability of these strains to support the endotoxin-induced liberation of tumour necrosis factor, interferon and heat-stable cytostatic factors in mouse circulation. Five strains caused good stimulation of macrophage functions and induced high levels of all factors. One strain was nearly lacking in macrophage stimulatory capacity and also failed to support factor production. These data are discussed in relation to the production mechanisms of the factors.

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